factor xiii การใช้

• Factor XIII completes the cross-linking of fibrin so that it hardens and contracts.
• Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade.
• This gene encodes the coagulation factor XIII A subunit.
• Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits.
• MASP-1 is also able to cleave fibrinogen and factor XIII and may be involved in coagulation.
• Factor XIII is activated by thrombin into factor XIIIa; its activation into Factor XIIIa requires cofactor.
• The gene, known as F13B, codes for part of Factor XIII in the cascade of blood-clotting proteins.
• In contrast to standard clotting tests, the fibrin stabilizing effect of factor XIII contributes to the result.
• Factor XIII levels are not measured routinely, but may be considered in patients with an unexplained bleeding tendency.
• Platelet factor XIII is composed of just 2 A subunits, which are identical to those of plasma origin.
• Both the activation of factor XIII by thrombin and plasminogen activator ( t-PA ) are catalyzed by fibrin.
• He was a co-discoverer of factor XIII, which was formerly referred to as Laki-Lorand factor and fibrin stabilizing factor.
• Loewy made his Factor XIII discoveries in the 1950s and 1960s, starting when he was doing postdoctoral work at Harvard.
• Some of the proteins synthesized by the liver include coagulation factors XIII, as well as protein C, protein S and antithrombin.
• He identified an enzyme, called Factor XIII, that binds proteins together to form what amounts to a plug in the wound.
• Deficiency of Factor XIII leads to defective cross-linking of fibrin and vulnerability to late re-bleeds when the primary hemostatic plug is overwhelmed.
• Factor XIII is a transglutaminase that circulates in the plasma as a heterotetramer of two catalytic A subunits and two carrier B subunits.
• Transglutaminases were first described in 1959 . The exact biochemical activity of transglutaminases was discovered in blood coagulation protein factor XIII in 1968.
• Besides aiding the overall understanding of clotting, his discoveries helped researchers develop treatments for people who have bleeding problems because they lack Factor XIII.
• During blood clotting, the fibronectin remains associated with the clot, covalently cross-linked to fibrin with the help of Factor XIII ( fibrin-stabilizing factor ).